I don't believe this is a big issue but on accident I left Mediaportal Configuration open, then started MP, and noticed that no remote buttons I pressed did anything. I could hear the audio confirmation but the screen stayed at the main start up screen. I could use the mouse with no problem. Issue went away if I closed the config program before opening MP.
Steps.
1) open mediaportal configuration.
2) run MP
3) test remote functionality
Steps.
1) open mediaportal configuration.
2) run MP
3) test remote functionality