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I have no idea, but would be curious to know. I think that if you have the MS Speech engine it should be fine. It works with engines 5.1 and 6.1 (the one that comes with MS Office 2003), but I'm unsure as to whether they've change speech engines for Vista. You can find out what engine you're using by going to Control Panel->Speech and it'll be in the Language drop-down (instructions are for XP btw, as I don't know the Vista equivalent).