The main problem I have is that I've found it impossible to reliably get exactly one button press registered per actual button press. No matter what delays, # times sending codes, etc that I configure for the logitech, sometimes it will register 2 button presses for a single actual press.
After wrestling with it for a couple of days, I gave up and bought the MCE-compatible remote. Everything working properly (via EventGhost) within an hour.
It's possible that if I'd worked with the Logitech technicians the problems could have been solved, but the iMON software itself is very limiting compared to something like EventGhost.
I worked alot with the Harmony-people to get a good speed while avoiding the double-clicking aswell, and I gave up, but then I found the speed settings in the Imon Manager and now it works perfectly. Don't know if you have tried those.