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Wish I could help you, but I do not really know the cause of that error.

A few things that I would have done:

Although you stated you already tried it, make sure you followed the "defender breaks localhost" steps to the letter. Make sure the file you edit is called host - WITHOUT any extension. Is your Explorer/MyComputer configured to show all file extensions? If not, one might be under the impression that there is no extension but in the mean time Notepad saved it as .txt. Unlikely, but just make sure.

https://forum.team-mediaportal.com/newcomers-forum-240/windows-defender-breaks-localhost-56258/

Try the loopback-instructions in the manual.

TV-Server/FAQ - MediaPortal Manual Documentation

https://forum.team-mediaportal.com/newcomers-forum-240/msloopback-device-singleseat-users-51028/#post348973

Running on an administrator account? If not, try and see if there is a difference.

Re-read the manual instructions on

- MS SQL Server Installation

- MS SQL Server Configuration

or

- MySQL Installation

Also re-read the following manual pages:

- TV-Server/install-TV-Server - MediaPortal Manual Documentation

- TV-Server/Configuration/Firewall - MediaPortal Manual Documentation

- TV-Server/Configuration - MediaPortal Manual Documentation

Really hope you pick up something in there that will solve the problem.

Good luck