There is only one hard thing if you want to use the microsoft mce remote you have to install the vista mce replacement drivers and the mce replacment plugin for MP.
I've been tinkering around with the 64bit version of Windows 7, and I have 'issues' with the Microsoft MCE remote on MediaPortal. Some of the controls work and some don't. You mentioned above about installing the 'vista mce replacement drivers and the mce replacement plugin', and I have no idea where you get these from?
Can you help me out mate?
Thanks.
Otherwise MediaPortal seems to run superbly on Windows 7 beta build 7000!!