Germany
No it doesn't. You manually need to exchange the Database Plugin in MP2 server to use MySQL. But the MySQL plugin is very old, no longer maintained and most likely no longer working. So it's strictly recommended to NOT use it unless you're in a desperate need for MySQL and you know exactly what you are doing.
This is because SQLite is at least 5 times as fast as MySQL. This is no theoretical value, we've measured this during development of the SQLiteDB plugin in real live tests with various very small up to really big sized DB files from very few up to half a million media items. The average plus in performance was from 500% up to 1000% compared to MySQL...
Aside this, SQLite did not need installation, configuration and maintenance of a full blown SQL server. It runs with a simple .dll file, that don't need any installation or configuration.
The main drawback of SQLite is that it should be (write-) accessed only from one client at a time. As in MP2 only the Server Process is allowed to access the DB this is no issue at all...
